Fumio Takaiwa Selected Research

Proteins (Proteins, Gene)

1/2015	Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.
12/2014	Generation of transgenic rice with reduced content of major and novel high molecular weight allergens.
10/2014	Suppression of collagen-induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of type II collagen.
9/2014	Generation mechanism of novel, huge protein bodies containing wild type or hypoallergenic derivatives of birch pollen allergen Bet v 1 in rice endosperm.
1/2014	Prophylactic effect of the oral administration of transgenic rice seeds containing altered peptide ligands of type II collagen on rheumatoid arthritis.
8/2013	Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.
6/2013	Transgenic rice seeds accumulating recombinant hypoallergenic birch pollen allergen Bet v 1 generate giant protein bodies.
12/2011	Generation of transgenic rice lines with reduced contents of multiple potential allergens using a null mutant in combination with an RNA silencing method.
12/2011	Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression.
8/2010	Rice seed ER-derived protein body as an efficient delivery vehicle for oral tolerogenic peptides.

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Fumio Takaiwa Research Topics

Disease

21	Seasonal Allergic Rhinitis (Hay Fever) 01/2021 - 09/2005
18	Hypersensitivity (Allergy) 01/2021 - 11/2005
4	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 11/2021 - 05/2015
4	Autoimmune Diseases (Autoimmune Disease) 02/2018 - 12/2012
3	Asthma (Bronchial Asthma) 12/2011 - 01/2009
2	Conjunctivitis 11/2021 - 11/2018
2	Arthritis (Polyarthritis) 05/2017 - 01/2017
2	Alzheimer Disease (Alzheimer's Disease) 01/2015 - 08/2010
2	Dermatitis 12/2014 - 12/2011
2	Eczema 12/2014 - 12/2011
2	Food Hypersensitivity (Food Allergy) 12/2014 - 12/2011
2	Rheumatoid Arthritis 10/2014 - 01/2014
2	Inflammation (Inflammations) 01/2012 - 07/2010
2	Hypertension (High Blood Pressure) 12/2009 - 05/2006
2	Infections 06/2007 - 12/2006
2	Sneezing 02/2007 - 12/2006
1	Sialadenitis 09/2020
1	Rhinitis 11/2018
1	Memory Disorders (Memory Loss) 01/2015
1	Experimental Arthritis 10/2014
1	Leukemia 08/2014
1	Anaphylaxis (Anaphylactic Shock) 08/2014
1	Hypercholesterolemia 04/2011
1	Body Weight (Weight, Body) 04/2011
1	Amyloid Plaque 08/2010
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2010
1	Diarrhea 05/2010
1	Parasitic Diseases (Parasitic Disease) 04/2009
1	Dust Mite Allergy 01/2008
1	Communicable Diseases (Infectious Diseases) 06/2007
1	Iron Deficiencies 05/2002

Drug/Important Bio-Agent (IBA)

28	AllergensIBA 11/2021 - 11/2005
22	VaccinesIBA 11/2021 - 12/2006
13	Peptides (Polypeptides)IBA 01/2021 - 11/2005
13	AntigensIBA 01/2019 - 12/2006
11	Immunoglobulin E (IgE)IBA 01/2021 - 09/2005
11	Proteins (Proteins, Gene)FDA Link 01/2015 - 11/2007
10	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2021 - 11/2005
6	LigandsIBA 09/2020 - 01/2014
6	TolerogenIBA 01/2015 - 11/2007
4	Dermatophagoides pteronyssinus antigen p 1IBA 01/2012 - 01/2008
3	Interleukin-17 (Interleukin 17)IBA 09/2020 - 01/2017
3	Protein Subunit VaccinesIBA 08/2014 - 09/2005
3	CytokinesIBA 07/2010 - 11/2005
2	Therapeutic UsesIBA 11/2021 - 10/2014
2	AntibodiesIBA 05/2017 - 01/2017
2	GlobulinsIBA 12/2014 - 12/2011
2	Collagen Type II (Type II Collagen)IBA 10/2014 - 01/2014
2	Glutens (Glutelin)IBA 06/2013 - 04/2011
2	Histamine (Histamine Dihydrochloride)FDA Link 02/2007 - 12/2006
2	Interleukin-4 (Interleukin 4)IBA 12/2006 - 11/2005
2	Interleukin-13IBA 12/2006 - 11/2005
2	Interleukin-5 (Interleukin 5)IBA 12/2006 - 11/2005
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 09/2020
1	Anti-Allergic Agents (Antiallergic Agents)IBA 11/2018
1	Mast Cell StabilizersIBA 11/2018
1	Histamine Antagonists (Antihistamines)IBA 11/2018
1	Ophthalmic Solutions (Eye Drops)IBA 11/2018
1	Messenger RNA (mRNA)IBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2015
1	Carrier Proteins (Binding Protein)IBA 12/2014
1	GlucosidasesIBA 12/2014
1	Histocompatibility Antigens Class IIIBA 08/2014
1	Protein Sorting Signals (Signal Peptide)IBA 06/2013
1	DNA (Deoxyribonucleic Acid)IBA 06/2013
1	Interleukin-10 (Interleukin 10)IBA 12/2012
1	Dermatophagoides farinae antigen f 2IBA 05/2012
1	Subunit VaccinesIBA 12/2011
1	Lactoylglutathione LyaseIBA 12/2011
1	Trypsin InhibitorsIBA 12/2011
1	Amylases FDA Link 12/2011
1	Lactoglobulins (beta-Lactoglobulin)FDA Link 04/2011
1	HDL CholesterolIBA 04/2011
1	LDL Lipoproteins (beta Lipoproteins)IBA 04/2011
1	LDL CholesterolIBA 04/2011
1	lactostatinIBA 04/2011
1	HDL LipoproteinsIBA 04/2011
1	gamma-sitosterol (beta-sitosterol)IBA 04/2011
1	Pharmaceutical PreparationsIBA 04/2011
1	Amyloid beta-PeptidesIBA 08/2010
1	InterleukinsIBA 07/2010
1	Secretory Immunoglobulin A (SIgA)IBA 05/2010
1	Cholera ToxinIBA 05/2010
1	Enterotoxins (Enterotoxin)IBA 05/2010
1	Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)IBA 05/2010
1	gamma-Aminobutyric Acid (GABA)IBA 12/2009
1	Edible VaccinesIBA 01/2009
1	ProlaminsIBA 11/2007
1	Cysteine (L-Cysteine)FDA Link 11/2007
1	IronIBA 05/2002
1	Ferritins (Ferritin)IBA 05/2002
1	SolutionsIBA 05/2002

Therapy/Procedure

23	Immunotherapy 11/2021 - 09/2005
15	Oral Administration 11/2021 - 09/2005
1	Subcutaneous Injections 08/2014